Cuero is a city in DeWitt County, Texas, United States. The population was 6,841 at the 2010 census. It is the county seat of DeWitt County. The city of Cuero had its start in the mid-19th century as a stopping point on the Chisholm Trail cattle route to Kansas. However, it was not recognized as a town until 1873, when it was officially founded. The city was named for the Spanish word meaning “hide”, referring to the leather made from animal hides. The industry was extremely short-lived, however, and gave way to various forms of ranching. The city had several Old West gunfights related to clan feuding following the Civil War.